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首页> 外文OA文献 >Experimental Studies on the Modification of Urinary Alanine Aminopeptidase (AAP) and N-Acetyl--D-Glucosaminidase (NAG) in Patients Submitted to Intraperitoneal Hyperthermic Chemoperfusion (HIIP)
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Experimental Studies on the Modification of Urinary Alanine Aminopeptidase (AAP) and N-Acetyl--D-Glucosaminidase (NAG) in Patients Submitted to Intraperitoneal Hyperthermic Chemoperfusion (HIIP)

机译：腹腔热灌注化疗（HIIp）患者尿丙氨酸氨肽酶（aap）和N-乙酰-D-氨基葡萄糖苷酶（NaG）修饰的实验研究

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Introduction: NAG and AAP have been utilized as indicators of renal disease or tubular damage. This study was aimed at analysing the variation of enzymes value in patients submitted to HIIP. Methods: The 24-hours urinary escretion of NAG and AAP was measured on p.o. day 3 in 46 patients who underwent HIIP for peritonealcarcinomatosis (TG) and in 25 patients submitted to major surgical procedures (CG). Results: In the CG, a significant difference between mean preoperative and p.o. values of NAG (5.8 vs. 10; p 0.04) were observed. A difference between mean p.o. values of NAG (25.4 vs. 10; p 0.01) and AAP (29 vs. 16.8; p 0.07) was observed in TGwith respect to CG. In TG, complications were observed in 41.3%. No differences in mean value of NAG and AAP were observed according to overall complications (p 0.20 and p 0.28), also considering surgical (p 0.11 and p 0.45) or medical separately (p 0.53 and p 0.80). An extremely high value of urinary enzymes was observed in patients with intestinal fistula and fluid collection (NAG: 62.7 and67; AAP: 27.2 and 81.9). In TG, a significantly higher value of enzymes was observed for patients with grade 2–3 renal toxicity (NAG: 59.6; p 0.001; AAP: 61.9; p 0.006). No difference was observed according to other variables.Discussion: p.o. value of NAG and AAP was significantlyhigher in TG in relation to tubular damage induced to treatment. p.o. assessment of enzymes should play a role in prediction of septic surgical related complications as well as severe renal toxicity.
机译：简介：NAG和AAP已被用作肾脏疾病或肾小管损害的指标。这项研究旨在分析HIIP患者中酶值的变化。方法：p.o测定24小时尿中NAG和AAP的排泄量。第3天，有46例因腹膜癌（TG）接受HIIP治疗的患者和25例接受了大手术（CG）的患者。结果：在CG中，平均术前与p.o之间存在显着差异。观察到NAG值（5.8 vs. 10; p 0.04）。平均p.o之间的差异TG相对于CG观察到NAG（25.4 vs. 10; p 0.01）和AAP（29 vs. 16.8; p 0.07）的值。在TG中，观察到并发症的发生率为41.3％。根据总体并发症（p 0.20和p 0.28），手术（p 0.11和p 0.45）或医疗方面（p 0.53和p 0.80），NAG和AAP的平均值均无差异。在肠瘘和积液的患者中观察到尿酶值极高（NAG：62.7和67； AAP：27.2和81.9）。在TG中，观察到具有2-3级肾毒性的患者的酶值显着更高（NAG：59.6； p 0.001； AAP：61.9； p 0.006）。根据其他变量未观察到差异。与治疗引起的肾小管损害相比，TG中NAG和AAP的值显着较高。点酶的评估应在化脓性外科手术相关并发症以及严重的肾毒性的预测中发挥作用。

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